Alcohol Treatment, Pharmacotherapy, and Recovery Research (R01 Clinical Trial Required) | PAR 23 250

Opportunity Information: Apply for PAR 23 250

The National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH), is offering a discretionary grant opportunity titled "Alcohol Treatment, Pharmacotherapy, and Recovery Research (R01 Clinical Trial Required)" under Funding Opportunity Number PAR 23-250 (CFDA 93.273). This program uses the R01 mechanism and specifically requires that proposed projects include a clinical trial, meaning applicants should be prepared to design and conduct human-subject research that prospectively assigns participants to an intervention in order to evaluate effects on health-related or behavioral outcomes relevant to alcohol use disorder (AUD).

The core purpose of the opportunity is to support research that improves the treatment of, and recovery from, AUD across a wide range of approaches. NIAAA is looking for studies that can move the field forward on medications development and pharmacotherapy, including the testing of new medication candidates and strategies for optimizing existing medications. A strong emphasis is also placed on precision medicine approaches, such as identifying which treatments work best for which individuals based on clinical profiles, biological measures, co-occurring conditions, or other patient-level characteristics. In addition, the notice highlights behavioral therapies and the mechanisms of behavioral change (MOBC), encouraging applicants not only to test whether an intervention works, but also to measure and explain how and why it works, which can strengthen treatment design and improve real-world effectiveness.

Beyond treatment efficacy, the opportunity explicitly includes recovery research, which can cover a broad set of outcomes and processes involved in sustaining improvements over time. This may include studying long-term remission and relapse patterns, recovery support strategies, and factors that influence functioning, quality of life, and stability after treatment. The NOFO also welcomes translational research that bridges basic science insights to clinical applications, as well as innovative methods and technologies that could improve access, engagement, personalization, monitoring, or outcomes in AUD treatment and recovery. Examples in this category often include novel service delivery models, digital or mobile supports, technology-enabled measurement of drinking or craving, and other creative tools designed to strengthen interventions or their implementation.

Eligibility is broad and includes many types of domestic U.S. organizations: state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); Native American tribal organizations (other than federally recognized tribal governments); public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); and small businesses. The NOFO also calls out additional eligible applicant types such as faith-based or community-based organizations, eligible federal agencies, regional organizations, and entities located in U.S. territories or possessions. It specifically notes a range of mission-focused institutions and organizations as eligible applicants, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISI). It also indicates that non-U.S. entities (foreign organizations) are eligible, and that Indian/Native American Tribal Governments that are not federally recognized are included among eligible applicants.

Key administrative details include an original closing date listed as 2026-09-07 and an award ceiling of $500,000 (as provided in the source data). The listing does not specify the expected number of awards. Overall, this NOFO is geared toward well-designed, clinically focused R01 projects that can generate actionable evidence about AUD treatment and recovery, including intervention development and testing, tailoring treatments to individuals, understanding behavioral mechanisms, supporting sustained recovery, translating science into practice, and using innovative technologies to improve outcomes.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Alcohol Treatment, Pharmacotherapy, and Recovery Research (R01 Clinical Trial Required)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273.
• This funding opportunity was created on 2023-08-09.
• Applicants must submit their applications by 2026-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $500,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 23 250

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