Opportunity Information: Apply for RFA HD 24 006
This grant opportunity, "Using Archived Data and Specimen Collections to Advance Maternal and Pediatric HIV/AIDS Research (R21 - Clinical Trial Not Allowed)" (RFA-HD-24-006), is a National Institutes of Health (NIH) discretionary grant designed to push maternal and pediatric HIV/AIDS research forward by making better use of resources that already exist. Instead of funding new clinical trials, the program focuses on secondary research, meaning investigators are expected to analyze archived datasets and/or stored biological specimens from prior studies or established collections. The main idea is to accelerate discovery by translating existing data into new insights, encouraging data sharing, and helping the field extract more value from prior investments in cohort studies, surveillance systems, and specimen repositories.
The scientific emphasis is on generating new questions and new findings that align with the mission and priorities of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), specifically its Maternal and Pediatric Infectious Disease Branch (MPIDB), along with the NIH Office of AIDS Research (OAR). Projects should aim to answer meaningful questions about HIV/AIDS in maternal, pediatric, and adolescent populations. The FOA highlights a broad range of topic areas where advanced analyses could make a difference, including the epidemiology of HIV in these groups (for example, trends in transmission, risk factors, and outcomes), pathogenesis (how HIV disease develops and interacts with immune function or co-infections), treatment (including ART-related outcomes, resistance patterns, adherence-related questions, or regimen comparisons using existing data), and the clinical manifestations and complications of HIV/AIDS in pregnancy, infancy, childhood, and adolescence. The announcement explicitly encourages applicants to bring in newer or more advanced analytic approaches, which can include modern statistical methods, causal inference strategies, and other cutting-edge techniques that can uncover relationships not addressed in the original studies.
Because this is an R21 mechanism, the intent is typically exploratory and developmental. That generally means the program is well-suited for innovative, proof-of-concept analyses, early-stage hypothesis generation, or testing novel analytic strategies on existing datasets or specimen-linked data, rather than large, long-term prospective research programs. The FOA also makes clear that clinical trials are not allowed, reinforcing that the work should be based on analysis of existing information and materials rather than enrolling participants into new interventional studies.
In terms of who can apply, the eligibility is broad and intentionally inclusive, spanning many organizational types. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (as long as they are not institutions of higher education when applying in that category); for-profit organizations other than small businesses; and small businesses. The FOA also explicitly calls out additional eligible groups such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISI). It also includes faith-based or community-based organizations, eligible federal agencies, U.S. territories or possessions, and even non-U.S. entities (foreign organizations) and regional organizations, signaling an interest in drawing from diverse data resources and perspectives, including global archived cohorts where appropriate.
Key administrative details included in the posting are that the awarding agency is the NIH, the funding instrument is a grant, and the activity category is listed under Health, Income Security and Social Services. The CFDA numbers associated with the opportunity are 93.242 and 93.865. The original closing date was March 29, 2023, and the opportunity was created on November 22, 2022. The listed award ceiling is $275,000. While the posting notes "ExpectedAwards:" without a value shown in the provided text, the ceiling indicates the maximum amount that may be awarded per project under the terms of this announcement.
Overall, this FOA is essentially a targeted call to the maternal and pediatric HIV/AIDS research community to reuse and reanalyze existing archived data and specimen collections in smarter ways. The expected payoff is faster, cost-effective progress on high-priority questions affecting pregnant people, infants, children, and adolescents living with or exposed to HIV, while also strengthening the culture of data translation and sharing across the field.Apply for RFA HD 24 006
- The National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "Using Archived Data and Specimen Collections to Advance Maternal and Pediatric HIV/AIDS Research (R21 - Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242, 93.865.
- This funding opportunity was created on 2022-11-22.
- Applicants must submit their applications by 2023-03-29. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $275,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "Using Archived Data and Specimen Collections to Advance Maternal and Pediatric HIV/AIDS Research (R21 - Clinical Trial Not Allowed)" and is identified as RFA-HD-24-006.
Which federal agency is offering this funding?
The awarding agency is the National Institutes of Health (NIH).
What type of funding mechanism is this?
This is a discretionary NIH grant using the R21 mechanism, which is generally intended for exploratory and developmental research.
Are clinical trials allowed under this FOA?
No. The announcement explicitly states "Clinical Trial Not Allowed," meaning projects must not include new clinical trial enrollment or intervention testing.
What kind of research does this FOA support?
The FOA supports secondary research that analyzes archived datasets and/or stored biological specimens from prior studies or established collections, with the goal of producing new insights in maternal and pediatric HIV/AIDS.
What does "secondary research" mean in this context?
It means investigators are expected to work with existing information or materials (such as previously collected datasets, surveillance data, cohort data, or repository specimens) rather than collecting new data through prospective participant enrollment.
What is the overall purpose of the funding opportunity?
The program aims to accelerate discovery in maternal and pediatric HIV/AIDS research by translating existing data and specimen resources into new findings, encouraging data sharing, and maximizing the value of prior investments in cohorts, surveillance systems, and specimen repositories.
Which NIH institutes or offices are most closely associated with the scientific priorities of this FOA?
The FOA aligns with the mission and priorities of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), specifically its Maternal and Pediatric Infectious Disease Branch (MPIDB), and the NIH Office of AIDS Research (OAR).
What populations should the research focus on?
Projects should address meaningful HIV/AIDS questions in maternal, pediatric, and adolescent populations, including pregnancy, infancy, childhood, and adolescence.
What kinds of scientific topics are encouraged?
The FOA highlights a broad range of topics where advanced analyses could be impactful, including epidemiology, pathogenesis, treatment-related questions, and clinical manifestations and complications of HIV/AIDS in pregnancy and across early life stages.
What epidemiology questions are within scope?
Examples mentioned include trends in transmission, risk factors, and outcomes for maternal, pediatric, and adolescent populations, using existing data sources.
What pathogenesis-related work is within scope?
Pathogenesis topics include how HIV disease develops and how it interacts with immune function or co-infections, using archived data and/or stored specimens.
What treatment-related questions are within scope?
The FOA mentions antiretroviral therapy (ART)-related outcomes, resistance patterns, adherence-related questions, and regimen comparisons, as long as the work is conducted using existing datasets and/or specimen-linked data.
What clinical complications or manifestations are within scope?
The FOA encourages analyses of HIV/AIDS clinical manifestations and complications in pregnancy, infancy, childhood, and adolescence, based on existing information and materials.
Does the FOA encourage particular analytic approaches?
Yes. Applicants are encouraged to use newer or more advanced analytic approaches, including modern statistical methods, causal inference strategies, and other cutting-edge techniques that can reveal relationships not addressed in the original studies.
Is this FOA intended for large, long-term research programs?
The R21 mechanism is typically suited for innovative, exploratory, or proof-of-concept work, early-stage hypothesis generation, or testing novel analytic strategies, rather than large, long-term prospective research programs.
Do projects need to use both archived datasets and stored specimens?
The FOA indicates investigators are expected to analyze archived datasets and/or stored biological specimens. That wording supports projects using datasets only, specimens only, or a combination, so long as the materials come from prior studies or established collections.
What kinds of existing resources are the FOA aiming to leverage?
The opportunity emphasizes reusing resources such as cohort studies, surveillance systems, archived datasets, and specimen repositories/collections to generate new questions and findings.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S. and non-U.S. organizations, spanning government, education, nonprofit, and private-sector applicants.
Are state and local government entities eligible?
Yes. Eligible applicants include state governments and local government types such as county, city or township, and special district governments, as well as independent school districts.
Are universities and colleges eligible?
Yes. Both public/state-controlled institutions of higher education and private institutions of higher education are eligible.
Are nonprofit organizations eligible?
Yes. Nonprofit organizations with or without 501(c)(3) status are eligible (as long as they are not institutions of higher education when applying in that nonprofit category).
Are for-profit organizations eligible?
Yes. The FOA includes for-profit organizations other than small businesses, and it also includes small businesses as eligible applicants.
Are tribal organizations eligible?
Yes. Federally recognized Native American tribal governments and other Native American tribal organizations are included.
Are minority-serving institutions specifically identified as eligible?
Yes. The FOA explicitly includes groups such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISI).
Are faith-based or community-based organizations eligible?
Yes. The FOA states that faith-based or community-based organizations are eligible.
Are U.S. territories or possessions included?
Yes. U.S. territories or possessions are listed as eligible applicants.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are included in the eligible applicant types.
Are non-U.S. organizations allowed to apply?
Yes. The FOA indicates that non-U.S. entities (foreign organizations) and regional organizations are eligible, signaling interest in diverse perspectives and potentially global archived cohorts where appropriate.
What is the award ceiling (maximum award amount) listed?
The posting lists an award ceiling of $275,000, indicating the maximum amount that may be awarded per project under the terms of the announcement.
How many awards are expected?
The posting shows "ExpectedAwards:" but does not provide a value in the information provided here.
What are the CFDA numbers associated with this opportunity?
The CFDA numbers listed are 93.242 and 93.865.
What is the activity category listed for this funding opportunity?
The activity category is listed as Health, Income Security and Social Services.
When was the opportunity created?
The opportunity was created on November 22, 2022.
What was the original closing date?
The original closing date listed is March 29, 2023.
What is the main value proposition of this FOA for the research community?
The FOA is designed to produce faster, cost-effective progress on high-priority maternal and pediatric HIV/AIDS questions by reanalyzing existing datasets and specimen collections, generating new insights, and strengthening data translation and sharing across the field.
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